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Osamu Handa Selected Research

Immunotherapy

3/2017The JAK/STAT pathway is involved in the upregulation of PD-L1 expression in pancreatic cancer cell lines.
9/2013Whole blood interferon-γ levels predict the therapeutic effects of adoptive T-cell therapy in patients with advanced pancreatic cancer.
7/2011Adoptive cellular therapy enhances the helper T cell response and reduces the number of regulatory T cells.

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Osamu Handa Research Topics

Disease

31Inflammation (Inflammations)
11/2019 - 01/2002
29Colitis
07/2020 - 01/2002
23Neoplasms (Cancer)
01/2021 - 01/2003
15Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
07/2020 - 01/2002
12Stomach Neoplasms (Stomach Cancer)
01/2021 - 01/2002
10Ulcer
01/2021 - 03/2008
7Hemorrhage
01/2021 - 03/2008
7Ischemia
01/2018 - 01/2002
7Hyperthermia
07/2014 - 05/2007
6Ulcerative Colitis
05/2012 - 12/2008
5Wounds and Injuries (Trauma)
07/2019 - 07/2010
5Carcinogenesis
03/2018 - 01/2002
5Pancreatic Neoplasms (Pancreatic Cancer)
03/2017 - 05/2009
5Colonic Neoplasms (Colon Cancer)
07/2011 - 01/2003
4Body Weight (Weight, Body)
05/2021 - 01/2002
4Colorectal Neoplasms (Colorectal Cancer)
11/2018 - 02/2011
4Insulin Resistance
01/2016 - 05/2007
4Neoplasm Metastasis (Metastasis)
07/2014 - 01/2003
4Reperfusion Injury
03/2011 - 01/2002
3Stomach Ulcer (Gastric Ulcer)
01/2018 - 07/2010
3Polyps
06/2017 - 08/2012
3Enteritis
04/2013 - 03/2008
3Gastritis
01/2011 - 05/2004
2Irritable Bowel Syndrome (Syndrome, Irritable Bowel)
05/2022 - 01/2022
2Crohn Disease (Crohn's Disease)
03/2022 - 04/2013
2Diabetes Mellitus
10/2021 - 01/2016
2Constipation
10/2021 - 01/2020
2Metabolic Syndrome (Dysmetabolic Syndrome X)
05/2021 - 04/2013
2Intestinal Diseases (Diseases, Intestinal)
05/2021 - 12/2017
2Adenoma (Adenomas)
01/2021 - 03/2014
2Hyperglycemia
01/2021 - 04/2008
2Adenocarcinoma
01/2021 - 01/2021
2Diabetic Nephropathies (Diabetic Nephropathy)
01/2021 - 04/2008
2Pain (Aches)
01/2019 - 08/2013
2Esophageal Neoplasms (Esophageal Cancer)
12/2018 - 08/2016
2Type 2 Diabetes Mellitus (MODY)
01/2016 - 04/2008
2Hypersensitivity (Allergy)
06/2015 - 08/2013
2Lung Injury
01/2015 - 04/2007
2Infections
04/2013 - 12/2009

Drug/Important Bio-Agent (IBA)

20CytokinesIBA
11/2018 - 01/2002
14Proteins (Proteins, Gene)FDA Link
03/2018 - 01/2002
11Sulfonic AcidsIBA
03/2018 - 03/2006
10Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2022 - 01/2002
9Messenger RNA (mRNA)IBA
05/2021 - 01/2002
8Peroxidase (Myeloperoxidase)IBA
05/2021 - 03/2006
7Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
01/2021 - 03/2008
7Pharmaceutical PreparationsIBA
01/2021 - 11/2002
7Carbon MonoxideIBA
12/2018 - 04/2009
7Indomethacin (Indometacin)FDA LinkGeneric
02/2014 - 03/2008
7NF-kappa B (NF-kB)IBA
05/2009 - 01/2002
6Glucose (Dextrose)FDA LinkGeneric
05/2021 - 05/2007
6Dextran SulfateIBA
11/2019 - 01/2002
5Dextrans (Dextran)FDA Link
07/2020 - 05/2010
5sodium sulfate (sodium bisulfate)FDA LinkGeneric
07/2020 - 05/2010
5Nitric Oxide (Nitrogen Monoxide)FDA Link
12/2008 - 01/2002
4Biomarkers (Surrogate Marker)IBA
01/2021 - 04/2006
4Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
01/2021 - 03/2008
4Heme Oxygenase-1IBA
11/2019 - 12/2008
4Therapeutic UsesIBA
07/2019 - 08/2006
4Reactive Oxygen Species (Oxygen Radicals)IBA
01/2011 - 04/2007
4Transcription Factors (Transcription Factor)IBA
04/2008 - 04/2003
3Serotonin (5 Hydroxytryptamine)IBA
01/2022 - 07/2009
3guar gum (guaran)IBA
05/2021 - 01/2016
3GemcitabineFDA Link
03/2017 - 05/2009
3Phenobarbital (Luminal)FDA Link
10/2016 - 01/2002
3Insulin (Novolin)FDA Link
01/2016 - 05/2007
3Thiobarbituric Acid Reactive SubstancesIBA
01/2014 - 03/2006
3AdiponectinIBA
04/2013 - 03/2008
3rebamipideIBA
12/2012 - 03/2008
3Chemotactic FactorsIBA
09/2012 - 07/2009
3ZincIBA
11/2011 - 11/2002
3polaprezinc (Z 103)IBA
11/2011 - 11/2002
3Heat-Shock Proteins (Heat-Shock Protein)IBA
07/2011 - 01/2011
3LigandsIBA
03/2011 - 01/2002
3Pioglitazone (Actos)FDA Link
03/2011 - 01/2002
3DNA (Deoxyribonucleic Acid)IBA
12/2010 - 01/2006
3Interleukin-8 (Interleukin 8)IBA
02/2007 - 01/2002
2Volatile Fatty AcidsIBA
05/2022 - 05/2021
2Dietary FiberFDA Link
05/2021 - 01/2016
2Carotenoids (Carotene)IBA
01/2021 - 04/2008
2Capsules (Microcapsules)IBA
01/2021 - 01/2015
2EnzymesIBA
01/2021 - 12/2008
2astaxanthine (astaxanthin)IBA
01/2021 - 04/2008
2Peroxisome Proliferator-Activated Receptors (PPAR)IBA
11/2019 - 03/2011
2Substance PIBA
01/2019 - 08/2013
2Fluorouracil (Carac)FDA LinkGeneric
12/2018 - 03/2017
2Peptides (Polypeptides)IBA
11/2018 - 01/2016
2Proton Pump InhibitorsIBA
01/2018 - 01/2017
2Immunoglobulin G (IgG)IBA
01/2018 - 05/2015
2Hemoglobins (Hemoglobin)IBA
01/2017 - 05/2003
2Interleukin-6 (Interleukin 6)IBA
12/2015 - 02/2012
2Interleukin-17 (Interleukin 17)IBA
06/2014 - 02/2011
2MentholFDA Link
05/2014 - 03/2014
2Lipid PeroxidesIBA
01/2014 - 01/2002
2TropomyosinIBA
01/2014 - 01/2012

Therapy/Procedure

16Therapeutics
03/2022 - 01/2002
8Lasers (Laser)
01/2021 - 03/2014
7Enema (Enemas)
07/2020 - 03/2006
6Drug Therapy (Chemotherapy)
01/2019 - 11/2007
3Immunotherapy
03/2017 - 07/2011